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Within a recent review, we documented the identification and the characterization of a fresh atypical opioid receptor with one of a kind damaging regulatory Houses in the direction of opioid peptides.one Our effects confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a broad-spect
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Gene expression analysis discovered that ACKR3 is highly expressed in several brain locations similar to critical opioid action centers. In addition, its expression ranges are frequently increased than Individuals of classical opioid receptors, which even further supports the physiological relevance of its noticed in vitro opioid peptide scavenging
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